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Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Best Vitelliform Macular Dystrophy.

Stephen H Tsang^1,2, Tarun Sharma³

¹Jonas Children's Vision Care, Bernard & Shirlee Brown Glaucoma Laboratory, Columbia Stem Cell Initiative-Departments of Ophthalmology, Biomedical Engineering, Pathology & Cell Biology, Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Advances in Experimental Medicine and Biology

|December 23, 2018

Summary

This summary is machine-generated.

Best vitelliform macular dystrophy (BVMD) is a common inherited eye disease affecting 1 in 10,000 people. Its varied clinical presentation progresses through five distinct stages, impacting vision differently.

Keywords:

Autosomal dominant Best disease

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Area of Science:

Ophthalmology
Genetics
Retinal Diseases

Background:

Best vitelliform macular dystrophy (BVMD) is a prevalent inherited macular disease.
It affects approximately 1 in 10,000 individuals worldwide.
BVMD is characterized by progressive vision loss due to macular dysfunction.

Purpose of the Study:

To describe the clinical spectrum of Best vitelliform macular dystrophy.
To outline the characteristic stages of BVMD progression.
To enhance understanding of BVMD's varied presentation for improved diagnosis.

Main Methods:

Review of clinical case studies and imaging findings in BVMD patients.
Analysis of disease progression across documented stages.
Correlation of clinical presentation with disease stage.

Main Results:

BVMD presents with a variable clinical course.
The disease typically progresses through five recognized stages: Previtelliform, Vitelliform, Pseudohypopyon, Vitelliruptive, and Atrophic.
Each stage exhibits distinct ophthalmological findings.

Conclusions:

Best vitelliform macular dystrophy exhibits a well-defined, albeit variable, staging system.
Recognizing these stages is crucial for accurate diagnosis and patient management.
Further research into BVMD pathogenesis and treatment is warranted.