THE ROLE OF MELATONIN AND VITAMIN D IN IRAQI PREMENOPAUSAL WOMEN OSTEOARTHRITIS PATIENTS

Osteoarthritis (OA) is the most common form of arthritis, affecting 1 in 3 people over age 40 and women more so than men. The prevalence of OA is rising due to the increasing prevalence of OA risk factors, including obesity, physical inactivity, and joint injury. The aim of the study is to determine the correlation of Melatonin, Vitamin D (VitD) with osteoarthritis (OA) in women premenopausal OA women in age between 40-50 years old. The study included 60 patients with OA and 30 patients without OA from the general Balad Hospital in Salah Al-Den governorates. All subjects were premenopausal women between 40-50 years old. OA was diagnosed according to the clinical examination, X-ray diagnosis by Bone mineral density testing using STRATOS device, and biochemical tests using ELISA and COBOS 6000. This study proved that Melatonin is correlated with osteoarthritis in premenopausal women, there is a significant decrease (P≤0.01) in Melatonin (1.308+0.20 pg/dl), Vitamin D (22.82+1.53) mg/ml. Melatonin was positively correlated with vitamin D with no correlation with other biomarkers. Osteoarthritis in premenopausal women is strongly affected by Melatonin levels and Vitamin D, and it's recommended to use Melatonin and other chemical parameters as markers and potential therapeutic drugs.