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Evaluating Prenatal Diagnostic Imaging for Micrognathia: A Systematic Review and Meta-Analysis.
Caroline M Fields1, Nicolas S Poupore1, April N Taniguchi1
1Department of Otolaryngology - Head & Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Summary
Prenatal diagnosis of micrognathia missed over 10% of cases without mandibular measurements. Including these measurements significantly improved accuracy, aiding better prenatal planning and postnatal care for newborns.
Area of Science:
- Medical Imaging
- Prenatal Diagnosis
- Neonatal Care
Background:
- Micrognathia diagnosis and severity prediction prenatally have inconsistent results.
- Evaluating the reliability of prenatal diagnostic imaging for micrognathia is crucial.
Approach:
- Systematic review and meta-analysis of 16 studies involving 2753 neonates.
- Included studies with prenatal ultrasound diagnosis confirmed postnatally.
- Analyzed diagnostic accuracy with and without mandibular measurements, and linked prenatal severity to respiratory obstruction at birth.
Key Points:
- Missed prenatal diagnoses of micrognathia were 11.62% without mandibular measurements, significantly reduced to 0.20% with them.
- Prenatal imaging severity did not significantly correlate with increased risk of severe respiratory obstruction at birth.
- Mandibular measurements improve the accuracy of prenatal micrognathia diagnosis.
Conclusions:
- Prenatal diagnosis of micrognathia without mandibular measurements misses over 10% of cases.
- Incorporating mandibular measurements enhances diagnostic accuracy.
- Standardized objective criteria are needed for improved prenatal diagnosis and postnatal care planning.
