Related Experiment Video
Updated: Jul 11, 2025
04:12
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
934
Topical Treatments for Melasma and Post-inflammatory Hyperpigmentation.
Journal of Drugs in Dermatology : JDD
|November 9, 2023
Summary
Topical retinoids, like tazarotene, offer a safe and effective treatment for dyspigmentation such as melasma and post-inflammatory hyperpigmentation (PIH) when other options have limitations.
Area of Science:
- Dermatology
- Cosmetic Science
Background:
- Dyschromia, including melasma and post-inflammatory hyperpigmentation (PIH), is a common dermatological concern, particularly in individuals with skin of color.
- Current treatments face limitations regarding long-term safety, tolerability, or potential to worsen hyperpigmentation.
Purpose of the Study:
- To review topical treatments for melasma and PIH.
- To evaluate the efficacy and safety of the retinoid tazarotene for these conditions.
Main Methods:
- Qualitative review of topical treatments for melasma and PIH.
- Inclusion of data from an investigator-initiated trial on tazarotene.
Main Results:
- Triple combination hydroquinone (HQ) cream is a standard but not for long-term use due to safety concerns.
- Topical retinoids demonstrate efficacy and safety, with tolerability varying by dose and formulation.
- Tazarotene 0.045% polymeric emulsion lotion showed good efficacy, safety, and tolerability over 24 weeks in patients with moderate-to-severe melasma/PIH.
Conclusions:
- Multiple topical treatments exist for dyspigmentation, but many lack robust efficacy data or have safety/tolerability issues.
- Retinoids, exemplified by tazarotene, present a promising, safe, and effective therapeutic option for melasma and PIH.
Related Concept Videos
01:30Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
01:14Changes in Skin Color: Clinical Perspectives
2.0K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
2.0K
01:19Pigmentation
2.4K
The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
2.4K