Related Experiment Video
Updated: Jul 4, 2025
10:07
Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
Published on: October 8, 2021
1.4K
Smart Stimuli-Responsive Spherical Nucleic Acids: Cutting-Edge Platforms for Biosensing, Bioimaging, and Therapeutics
Xiaoqi Tang1, Shuang Zhao1, Jie Luo1
1Department of Clinical Laboratory Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), 30 Gaotanyan, Shapingba District, Chongqing, 400038, China.
Small (Weinheim an Der Bergstrasse, Germany)
|February 1, 2024
Summary
Stimuli-responsive spherical nucleic acids (SNAs) offer advanced solutions for molecular delivery challenges. This review highlights their potential in biosensing, bioimaging, and therapeutics by responding to internal and external triggers.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Molecular Biology
Background:
- Spherical nucleic acids (SNAs) possess excellent colloidal stability, modularity, and programmability, making them promising for molecular delivery.
- Traditional nanocarriers face limitations that stimuli-responsive SNAs can potentially overcome due to enhanced targeting and controllability.
Purpose of the Study:
- To provide a comprehensive overview of stimuli-responsive SNAs for biomedical applications.
- To highlight recent advancements in the design and utilization of SNA nanoplatforms.
- To offer guidance for developing novel stimuli-responsive SNAs.
Main Methods:
- Review of existing literature on stimuli-responsive SNAs.
- Analysis of SNA modifications for meeting biomedical demands.
- Categorization of SNAs based on responsive stimuli (internal and external).
Main Results:
- Stimuli-responsive SNAs demonstrate high targeting accuracy and controllability.
- SNAs engineered with multifunctional modifications show potential in biosensing, bioimaging, and therapeutics.
- Responsive behaviors to internal stimuli (sequence, enzyme, redox, pH) and external stimuli (light, temperature) are detailed.
Conclusions:
- Stimuli-responsive SNAs represent a robust strategy to advance nanocarrier technology.
- These nanoplatforms offer significant prospects for tailored diagnosis and treatment.
- Further rational design and development of stimuli-responsive SNAs are encouraged for diverse biomedical applications.
