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OPTN/SRTR 2022 Annual Data Report: COVID-19.
Jonathan M Miller1, Yoon Son Ahn2, Allyson Hart1
1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Medicine, Hennepin Healthcare, University of Minnesota, Minneapolis, MN.
Summary
Organ transplant recovery has improved since the Omicron variant, with lower posttransplant mortality and graft failure. The use of organs from donors testing positive for COVID-19 has increased, indicating a sustained recovery in organ transplantation.
Area of Science:
- Transplantation Medicine
- Infectious Disease Epidemiology
- Public Health Policy
Background:
- The COVID-19 pandemic significantly impacted organ transplantation, affecting donor availability and post-transplant outcomes.
- Previous reports highlighted concerns regarding posttransplant mortality and graft failure, particularly during the Omicron variant surge.
Purpose of the Study:
- To provide an updated analysis of COVID-19 trends in organ transplantation through November 12, 2022.
- To examine trends in the recovery of organ transplantation and the utilization of organs from donors with a positive COVID-19 test.
- To assess the impact of COVID-19 on posttransplant outcomes and compare current trends with previous data.
Main Methods:
- Analysis of organ transplant data up to November 12, 2022.
- Trend analysis of posttransplant mortality and graft failure rates.
- Evaluation of the utilization rates of organs from donors who tested positive for COVID-19.
Main Results:
- Posttransplant mortality and graft failure rates have decreased to lower levels, recovering from concerns noted during the Omicron variant wave.
- The utilization of organs from donors with a positive COVID-19 test has increased, especially after the first year of the pandemic.
- Most transplant measures show sustained recovery, potentially influenced more by policy changes than by ongoing COVID-19 concerns.
Conclusions:
- Organ transplant outcomes have largely recovered, with reduced posttransplant mortality and graft failure.
- Increased use of organs from donors with COVID-19 indicates adaptation and resilience in transplantation programs.
- Continued monitoring of COVID-19-related mortality is advised, but recovery trends suggest a shift towards policy-driven rather than pandemic-driven impacts on transplantation.
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