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Updated: May 25, 2025

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
Visible-Light-Induced Sulfonylation Cyclization to Generate Indole-Fused Medium-Sized N-Heterocycles in 2-Me-THF
Tongtong Shi1, Miao Tian1, Yanping Zhu1
1School of Pharmacy, Yantai University, Yantai 264005, P. R. China.
Abstract:
A novel visible-light-induced sulfonylation cyclization to indole-fused medium-sized N-heterocycles was established under room temperature with biomass-derived 2-Me-THF as the solvent. This reaction proceeds in the absence of external photocatalyst, additive, metal salts, and base. Broad substrate scope, good functional group compatibility, and large-scale synthesis and derivatization via iodination, nitration, chlorination, cyanation, and selenylation demonstrate the utility of this protocol. A radical cyclization route was proposed based on radical inhibition experiments, visible-light irradiation on-off test, apparent quantum efficiency calculation, and UV-vis absorption spectroscopic studies.
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