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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Enhanced depth imaging optical coherence tomography in type 2 diabetes.
Giuseppe Querques1, Rosangela Lattanzio, Lea Querques
1Department of Ophthalmology, University Vita Salute San Raffaele, Milan, Italy. giuseppe.querques@hotmail.it
Investigative Ophthalmology & Visual Science
|August 11, 2012
Summary
Diabetic retinopathy is associated with overall choroidal thinning, detectable by enhanced depth imaging optical coherence tomography (EDI OCT). This thinning may contribute to macular edema development in diabetic eyes.
Area of Science:
- Ophthalmology
- Diabetology
- Medical Imaging
Background:
- Diabetic retinopathy (DR) is a leading cause of vision loss.
- Macular edema is a common complication of DR.
- Choroidal thickness changes in DR are not fully understood.
Purpose of the Study:
- To investigate macular choroidal thickness variations in diabetic retinopathy stages.
- Utilize enhanced depth imaging optical coherence tomography (EDI OCT) for precise measurements.
Main Methods:
- Compared choroidal thickness in diabetic patients (no DR, NPDR without CSME, NPDR with CSME) using EDI OCT.
- Included a control group of healthy subjects matched for age and sex.
Main Results:
- Mean subfoveal choroidal thickness was significantly reduced in all diabetic groups compared to controls.
- No significant difference in choroidal thickness was observed among the different diabetic retinopathy stages.
Conclusions:
- Diabetic eyes exhibit overall choroidal thinning as visualized by EDI OCT.
- Reduced choroidal thickness may promote hypoxia and VEGF elevation, leading to macular edema.
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